As a major non-communicable disease, diabetes claims on average around 8% of total health budgets in developed countries. Diabetes is indiscriminate, but although risk increases with age, anyone can develop it. There are two types of diabetes:

Type 1 Caused by a deficiency, inherited and/or acquired, in production of insulin by the pancreas. This type requires daily administration of insulin. The cause of Type 1 diabetes is not yet known.

Type 2 The body produces insulin, but does not use it effectively.

Type 2 diabetes is more common than Type 1, and is usually caused by excess body weight and lack of physical activity.

Gestational diabetes This can occur in women who have never had diabetes before pregnancy. It develops when the body cannot produce enough insulin to cope with the changes during pregnancy. 

Tests to assess diabetes MeDia Diagnostics provides all the tests needed to accurately assess diabetes. Early and correct diagnosis is key in controlling this chronic disease. 

List of Diabetes tests

-Fructosamine

-Glucose

-HbA1c

Monitoring of Complications

-Albumin

-Creatinine

-Microalbumin

-b2-Microglobul.

-Urine Prot.

 

 

 

■  Fructosamine

Fructosamine (glycated serum protein) Serum fructosamine levels are elevated in diabetic patients with elevated blood glucose. When blood sugar levels are elevated, glucose binds to proteins such as albumin to form fructosamine, the concentration of which also increases.

Fructosamine is a much earlier indicator of diabetic control compared to HbA1c providing information on a person’s average blood glucose levels over the preceding 14-21 days. As such the American Diabetes Association recognises fructosamine as a useful tool in monitoring diabetes control.

Due to the shorter time span of fructosamine, it is often used to evaluate the effectiveness of medication changes and to monitor the treatment of gestational diabetes. The test is also particularly useful in situations where HbA1C cannot be reliably measured e.g. haemolytic anaemia, thalassemia or with genetic haemoglobin variants.

Benefits

üLiquid ready-to-use reagent

üEnzymatic method – offering improved specificity and reliability compared to conventional NBT-based methods. This method does not suffer from non-specific interferences unlike existing methods which can also be time consuming and difficult to automate

üStandardisation to the highest level – our fructosamine calibrator and control is assigned relative to human serum glycated with 14C-glucose, thus standardisation is to the highest level and directly reflects the nature of the patient sample.

üExcellent Sensitivity - 16µmol/l

üExcellent stability – stable on board the analyser for 28 days at +10 °C

üFully automated applications available for a wide range of clinical analysers.

FRUCTOSAMINE
FRUCTOSAMINE INSERT KIT
FRUTTOSAMINA_CE_ IT_1-260406.pdf
Documento Adobe Acrobat [232.4 KB]

Glucose

Glucose, a sugar, is the primary source of energy for the body. The body obtains glucose through the digestion of the sugar and starch in carbohydrates. Glucose is vital and interacts with the digestive and endocrine system. Due to this it is imperative to maintain glucose levels within the normal range.

Benefits

ü Liquid ready-to-use reagents available

ü Excellent sensitivity with a minimum level of detection determined as 0.060mmol/l (1.8mg/dl)

ü Fully automated applications available for a wide range of clinical analysers

üMeDia Diagnostici manufacture two kits for the measurement of glucose levels, including a GOD-PAP method and Hexokinase method using NAD+

GLUCOSE GOD-PAP
GLUCOSE GOD-PAP insert kit
GLUC_MR-6100_CE_ UK_2.3_20042011.pdf
Documento Adobe Acrobat [96.7 KB]
GLUCOSE HEXOKINASE
GLUCOSE HEXOKINASE insert kit
GLUC-HEX-290-OLY_ UK_1_12012012.pdf
Documento Adobe Acrobat [129.8 KB]

HbA1c (glycated haemoglobin)

Haemoglobin consists of four protein chains with four haem portions, and is located in red blood cells. Its main function is to transport oxygen in the blood. When glucose levels are elevated, the glucose binds to haemoglobin, changing it into HbA1c. The level of HbA1c correlates to the level of blood glucose. As red blood cells have a life span of four months, HbA1c gives an indication of long term control of a patient’s blood sugar levels.       

Benefits

ü Liquid ready-to-use reagent

ü Fully automated applications available for a wide range of clinical analysers

ü Suitable for use on whole blood samples

üMeDia Diagnostici manufacture three kits for the measurement of HbA1c levels, including a ion exchange resin, turbidimetric and enzymatic method .

HBA1 ION EXCHANGE RESIN
HBA1 ION EXCHANGE RESIN insert kit
HBA1_ CE_ IT_UK_1.pdf
Documento Adobe Acrobat [187.8 KB]
HBA1 AUTOMATION turbidimetric
HBA1 AUTOMATION turbidimetric insert kit
HBA1AUTOM_CE_UK_1.02-201109.pdf
Documento Adobe Acrobat [87.8 KB]
HBA1 AUTOMATION enzy,atic
HBA1 AUTOMATION enzymatic insert kit
HBA1AUTO-E_CE_UK_1-17122012.pdf
Documento Adobe Acrobat [412.0 KB]

Diabetes, monitoring of complications

Albumin

Albumin is the most abundant protein in serum with a high binding affinity to glucose. It has special relevance to people with diabetes because its presence in urine is a marker of diabetic kidney disease. Timely assessment of kidney disease will allow adjustment of treatment, improving patient diagnosis.

Benefits

ü Liquid ready-to-use reagents available

ü Fully automated applications available for a wide range of clinical analysers

ü Linear up to 50 g/l (5 g/dl)

ü Excellent sensitivity - 3.20g/dl

ALBUMIN BROMOCRESOL GREEN
ALBUMIN BROMOCRESOL GREEN enzymatic insert kit
ALBUMIN_CE_UK_1.06_20062011.pdf
Documento Adobe Acrobat [79.5 KB]

Creatinine

Creatinine is a waste product excreted from the blood into the urine via the kidney.

Kidney damage results in creatinine being retained in the blood. Creatinine clearance in the kidney gives a measure of the Glomerular Filtration Rate (GFR) and is the standard marker for renal function. Since its rate of excretion is constant, elevation of plasma creatinine is indicative of under-excretion, suggesting kidney impairment.

Benefits

ü Liquid ready-to-use reagents available

ü Excellent sensitivity of 26.4 µmol/l (0.29 mg/dl) in serum or plasma and 311 mol/l (3.51 mg/dl) in urine

ü Multiple matrices available including urine, plasma and serum

ü Fully automated applications available for a wide range of clinical analysers

ü Linear up to 32.5mg/dl in serum or plasma

üMeDia Diagnostici manufacture two kits for the measurement of creatinine levels, including a Jaffè method and Enzymatic method .

CREATININ JAFFE'
CREATININ JAFFE' insert kit
CREAT_100013-6100-CE_ UK_1_04112013.pdf
Documento Adobe Acrobat [246.1 KB]
CREATININ enzymatic
CREATININ enzymatic insert kit
CREAT-E-360-H911_CE_ UK_1_16102013.pdf
Documento Adobe Acrobat [395.3 KB]

Microalbumin

The MeDia Diagnostici Microalbumin assay detects the presence of albumin in the urine. In healthy individuals albumin is filtered by the kidneys, however if the kidneys are damaged small amounts of albumin leak into the urine. This is known as microalbuminuria and indicates early stages of nephropathy. Microalbumin is an excellent marker of kidney disease and can identify individuals with diabetic nephropathy approximately 5-10 years earlier than proteinuria tests reducing the incidence of end stage renal disease. As such the American Diabetes Association and Diabetes UK recommend all diabetics are screened for microalbuminuria on a yearly basis.

Benefits

ü Liquid ready-to-use reagents available

ü Wide measuring range - 5-230mg/l

ü Excellent Sensitivity – 5mg/l

ü Fully automated applications available for a wide range of clinical analysers

MICROALBUMIN
MICROALBUMIN insert kit
MICROALB150H912_CE_UK_0-20062011.pdf
Documento Adobe Acrobat [73.4 KB]

Urine Proteins

The renal execretion of moderate quantities of proteins could be an index of a beginner renal pathology expecially in diabetic subjects. The presence of light chanins immunoglobulins could be an index of kidney myeloma.

MeDia Diagnostici kit is a pirogallol red pigment based and permits a reliable quantification also of proteins classes different than albumin . Moreover thanks to the extended dynamic range and to the absence of pigment fixation on labware, the method is easily applicable to automatic analizers

Benefits

ü Excellent sensitivity to 0.007 g/L

ü The method is linear up to 2 g/L

ü Fully automated applications available for a wide range of clinical analysers

b-2-Microglobulin

Beta-2-Microglobulin (b-2-M) is a low molecular weight protein found on the surface of most cells, including white blood cells. In healthy individuals, b-2-M is synthesised at a rate of 9mg/hour and is eliminated mostly by the kidneys. When kidney disease is suspected, comparing blood and urine levels helps identify where the kidney is damaged. b-2-M is normally filtered out of the blood by the kidney’s tubules. In glomerular kidney disease, the glomeruli can’t filter it out of the blood, so levels increase in blood and decrease in urine. In tubular kidney disease, the tubules can’t reabsorb it back into the blood, so urine levels rise and blood levels fall. High levels of b -2-M in urine may help detect the early stages of kidney damage

b-2-Microglobulin
b-2-Microglobulin insert kit
B2M-H912_CE_IT_1.1_20072012.pdf
Documento Adobe Acrobat [326.0 KB]

Urine Proteins

The renal execretion of moderate quantities of proteins could be an index of a beginner renal pathology expecially in diabetic subjects. The presence of light chanins immunoglobulins could be an index of kidney myeloma.

MeDia Diagnostici kit is a pirogallol red pigment based and permits a reliable quantification also of proteins classes different than albumin . Moreover thanks to the extended dynamic range and to the absence of pigment fixation on labware, the method is easily applicable to automatic analizers

Benefits

ü Liquid ready-to-use reagents available

ü Excellent sensitivity to 0.007 g/L

ü The method is linear up to 2 g/L

ü Fully automated applications available for a wide range of clinical analysers

ü Multiple matrices available including urine and cerebrospinal fluid

URINE PROTEINS
URINE PROTEINS insert kit
PTOTHS-BC-530OLY-CE- UK-0-20032012.pdf
Documento Adobe Acrobat [448.9 KB]

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